Application

Research CategoryNeuroscience

Research Sub CategoryDevelopmental Signaling

Anti-Dopamine D2 Receptor Antibody is an antibody against Dopamine D2 Receptor for use in Immunohistochemistry.

Immunohistochemistry Analysis: A representative lot detected Dopamine D2 Receptor in WT mouse striatum tissue (Trifilieff, P., et al. (2013). Molecular Psychiatry. 18:102-1033).
Immunohistochemistry Analysis: A representative lot detected Dopamine D2 Receptor in wild-type and not in D2R knockout mouse sriatum tissue (Trifilieff, P., et al. (2011). BioTechniques. 50:111-118).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

The Dopamine D2 Receptor is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. 2 isoforms are reported for the D2 Dopamine Receptor, Isoform 1 and isoform 2 which are expressed in the pituitary and brain; Isoform 1 is expressed seven times more than isoform 2 in the caudate nucleus.

Immunogen

Recombinant protein corresponding to the cytoplasmic domain of mouse Dopamine D2 Receptor.

Epitope: cytoplasmic third intracellular loop

Other Notes

Concentration: Please refer to lot specific datasheet.

Physical form

Purified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide.

Affinity

Quality

Evaluated by Immunohistochemistry in mouse striatum tissue.

Immunohistochemistry Analysis: A 1:250 dilution of this antibody detected Dopamine D2 Receptor in mouse striatum tissue.

Specificity

This antibody binds to the cytoplasmic third intracellular loop.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

50.9 kDa calculated